Existing Medication Can Treat Major Depression


Existing medication can treat major depression. Researchers have identified a drug that can be used in the treatment of depression.

Depression is a serious mood disorder which can cause disability and damage health. Worldwide about 300 million people have the condition, according to the World Health Organization (WHO).

In 2016, in America, over 10 million adults had at least single major depressive episode. The current treatments are not enough to treat this condition from its roots and more than 30 percent of depression sufferers are resistant to treatment.

Now, researchers at the Icahn School of Medicine at Mount Sinai in New York City, NY, have found that existing anticonvulsant drug called ezogabine can help reduce the symptoms.

They used the drug in their study which involved 18 participants who had experienced a depressive episode. The study by Dr. James Murrough, the director of the Mood and Anxiety Disorders Program at the Icahn School of Medicine and colleagues, now features in n the journal Molecular Psychiatry.

The team administered more than 900 milligrams of ezogabine orally to these participants for a period of 10 weeks. Then they used MRI scanner to scan the brain circuitry pre- and post-treatment in these peoples.

They found that ezogabine reduced depressive symptoms by a 45 percent.

“Most antidepressants are in the same class of drugs and work by increasing serotonin. Our research suggests a different molecular target that works through other brain mechanisms and could be helpful for patients,” notes Dr. James Murrough, who is also a senior author of the paper.



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